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Mouse DNA topoisomerase 2-binding protein 1 (aa 1-1515 )

Topbp1 Swiss Prot#

Q6ZQF0

Topbp1 Protein names

DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)

Topbp1 Gene names

Topbp1 Kiaa0259

Organism

Mus musculus (Mouse)

Topbp1 Entry name

TOPB1_MOUSE

Topbp1 Codon optimized cDNA(gene) Clone

Topbp1 Cat #

RPY2537

Tag

Topbp1 contains A 6x histidine tag

Topbp1 Formulation

Liquid

Topbp1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Topbp1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Topbp1 Protein

Topbp1 Cat #

PY2537

Topbp1 Source

recombinant

Topbp1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Topbp1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Topbp1 Activity

N/A

Tag

Topbp1 Contains A 6x histidine tag

Topbp1 Formulation

Liquid

Topbp1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Topbp1 family

-

Topbp1 Subcellular locations

Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Chromosome.

Topbp1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (By similarity). May play a role in spermatogenesis.

Topbp1 Sequence

DDBJ

EMBL

GenBank

Topbp1 3D structure

ModBase

Topbp1 interaction

STRING

Topbp1 Proteomic

PRIDE

Topbp1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Topbp1 Organism specific

CTD

MGI

Topbp1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Topbp1 Gene expression

Bgee

ArrayExpress

Genevestigator

Topbp1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY