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Rat Insulin receptor (aa 1-1383 )

Insr Swiss Prot#

P15127

Insr Protein names

Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

Insr Gene names

Insr

Organism

Rattus norvegicus (Rat)

Insr Entry name

INSR_RAT

Insr Codon optimized cDNA(gene) Clone

Insr Cat #

RPY2476

Tag

Insr contains A 6x histidine tag

Insr Formulation

Liquid

Insr Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Insr Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Insr Protein

Insr Cat #

PY2476

Insr Source

recombinant

Insr Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Insr Purity

>90%, as determined by SDS-PAGE under reducing conditions

Insr Activity

N/A

Tag

Insr Contains A 6x histidine tag

Insr Formulation

Liquid

Insr Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Insr family

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily

Insr Subcellular locations

Membrane; Single-pass type I membrane protein.

Insr FUNCTION According to UniProtKB Swiss Prot

FUNCTION: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K).

Insr Sequence

DDBJ

EMBL

GenBank

Insr 3D structure

ModBase

Insr interaction

STRING

Insr Proteomic

PRIDE

Insr Genome annotation

Ensembl

GeneID

KEGG

UCSC

Insr Organism specific

CTD

MGI

Insr Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Insr Gene expression

Bgee

ArrayExpress

Genevestigator

Insr Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY