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Human Myosin-VI (aa 1-1294 )

MYO6 Swiss Prot#

Q9UM54

MYO6 Protein names

Myosin-VI (Unconventional myosin-6)

MYO6 Gene names

MYO6 KIAA0389

Organism

Homo sapiens (Human)

MYO6 Entry name

MYO6_HUMAN

MYO6 Codon optimized cDNA(gene) Clone

MYO6 Cat #

RPY2444

Tag

MYO6 contains A 6x histidine tag

MYO6 Formulation

Liquid

MYO6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MYO6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MYO6 Protein

MYO6 Cat #

PY2444

MYO6 Source

recombinant

MYO6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MYO6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MYO6 Activity

N/A

Tag

MYO6 Contains A 6x histidine tag

MYO6 Formulation

Liquid

MYO6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MYO6 family

-

MYO6 Subcellular locations

Golgi apparatus > trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus. Nucleus. Cytoplasm > perinuclear region. Membrane > clathrin-coated pit. Cell projection > ruffle membrane; Peripheral membrane protein. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Cell projection > ruffle membrane.

MYO6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).

MYO6 Sequence

DDBJ

EMBL

GenBank

MYO6 3D structure

ModBase

MYO6 interaction

STRING

MYO6 Proteomic

PRIDE

MYO6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MYO6 Organism specific

CTD

MGI

MYO6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MYO6 Gene expression

Bgee

ArrayExpress

Genevestigator

MYO6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY