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Human Tubulin-specific chaperone D (aa 1-1192 )

TBCD Swiss Prot#

Q9BTW9

TBCD Protein names

Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)

TBCD Gene names

TBCD KIAA0988 SSD1 TFCD PP1096

Organism

Homo sapiens (Human)

TBCD Entry name

TBCD_HUMAN

TBCD Codon optimized cDNA(gene) Clone

TBCD Cat #

RPY2380

Tag

TBCD contains A 6x histidine tag

TBCD Formulation

Liquid

TBCD Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TBCD Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TBCD Protein

TBCD Cat #

PY2380

TBCD Source

recombinant

TBCD Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TBCD Purity

>90%, as determined by SDS-PAGE under reducing conditions

TBCD Activity

N/A

Tag

TBCD Contains A 6x histidine tag

TBCD Formulation

Liquid

TBCD Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TBCD family

TBCD family

TBCD Subcellular locations

Cell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction.

TBCD FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.

TBCD Sequence

DDBJ

EMBL

GenBank

TBCD 3D structure

ModBase

TBCD interaction

STRING

TBCD Proteomic

PRIDE

TBCD Genome annotation

Ensembl

GeneID

KEGG

UCSC

TBCD Organism specific

CTD

MGI

TBCD Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TBCD Gene expression

Bgee

ArrayExpress

Genevestigator

TBCD Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY