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| Rat Phosphatidylinositol-3 4 5-trisphosphate 5-phosphatase 1 (aa 1-1190 ) |
| Ship Swiss Prot# | | P97573 |
| Ship Protein names | | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.n1) (SH2 domain-containing inositol-5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) |
| Ship Gene names | | Inpp5d Ship Ship1 |
| Organism | | Rattus norvegicus (Rat) |
| Ship Entry name | | SHIP1_RAT |
| Ship Codon optimized cDNA(gene) Clone |
| Ship Cat # | | RPY2378 |
| Tag | | Ship contains A 6x histidine tag |
| Ship Formulation | | Liquid |
| Ship Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Ship Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Ship Protein |
| Ship Cat # | | PY2378 |
| Ship Source | | recombinant |
| Ship Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Ship Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Ship Activity | | N/A |
| Tag | | Ship Contains A 6x histidine tag |
| Ship Formulation | | Liquid |
| Ship Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Ship Products | | For pricing and availability Click Here >>> |
| Ship family | | Inositol-1,4,5-trisphosphate 5-phosphatase family |
| Ship Subcellular locations | | Cytoplasm. Membrane; Peripheral membrane protein. |
| Ship FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity). |
| Ship Sequence | | DDBJ | EMBL | GenBank |
| Ship 3D structure | | ModBase |
| Ship interaction | | STRING |
| Ship Proteomic | | PRIDE |
| Ship Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Ship Organism specific | | CTD | MGI |
| Ship Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Ship Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Ship Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
