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Human Rho guanine nucleotide exchange factor 18 (aa 1-1173 )

ARHGEF18 Swiss Prot#

Q6ZSZ5

ARHGEF18 Protein names

Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)

ARHGEF18 Gene names

ARHGEF18 KIAA0521

Organism

Homo sapiens (Human)

ARHGEF18 Entry name

ARHGI_HUMAN

ARHGEF18 Codon optimized cDNA(gene) Clone

ARHGEF18 Cat #

RPY2367

Tag

ARHGEF18 contains A 6x histidine tag

ARHGEF18 Formulation

Liquid

ARHGEF18 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARHGEF18 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARHGEF18 Protein

ARHGEF18 Cat #

PY2367

ARHGEF18 Source

recombinant

ARHGEF18 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARHGEF18 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARHGEF18 Activity

N/A

Tag

ARHGEF18 Contains A 6x histidine tag

ARHGEF18 Formulation

Liquid

ARHGEF18 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARHGEF18 family

-

ARHGEF18 Subcellular locations

Cytoplasm.

ARHGEF18 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.

ARHGEF18 Sequence

DDBJ

EMBL

GenBank

ARHGEF18 3D structure

ModBase

ARHGEF18 interaction

STRING

ARHGEF18 Proteomic

PRIDE

ARHGEF18 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARHGEF18 Organism specific

CTD

MGI

ARHGEF18 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARHGEF18 Gene expression

Bgee

ArrayExpress

Genevestigator

ARHGEF18 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY