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Mouse Arf-GAP SH3 domain ANK repeat PH domain-containing 1 (aa 1-1147 )

Ddef1 Swiss Prot#

Q9QWY8

Ddef1 Protein names

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)

Ddef1 Gene names

Asap1 Ddef1 Kiaa1249 Shag1

Organism

Mus musculus (Mouse)

Ddef1 Entry name

ASAP1_MOUSE

Ddef1 Codon optimized cDNA(gene) Clone

Ddef1 Cat #

RPY2359

Tag

Ddef1 contains A 6x histidine tag

Ddef1 Formulation

Liquid

Ddef1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ddef1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ddef1 Protein

Ddef1 Cat #

PY2359

Ddef1 Source

recombinant

Ddef1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ddef1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ddef1 Activity

N/A

Tag

Ddef1 Contains A 6x histidine tag

Ddef1 Formulation

Liquid

Ddef1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ddef1 family

-

Ddef1 Subcellular locations

Cytoplasm. Membrane.

Ddef1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Posseses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.

Ddef1 Sequence

DDBJ

EMBL

GenBank

Ddef1 3D structure

ModBase

Ddef1 interaction

STRING

Ddef1 Proteomic

PRIDE

Ddef1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ddef1 Organism specific

CTD

MGI

Ddef1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ddef1 Gene expression

Bgee

ArrayExpress

Genevestigator

Ddef1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY