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Rat Proline- glutamic acid- leucine-rich protein 1 (aa 1-1130 )

Mnar Swiss Prot#

Q56B11

Mnar Protein names

Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor)

Mnar Gene names

Pelp1 Mnar

Organism

Rattus norvegicus (Rat)

Mnar Entry name

PELP1_RAT

Mnar Codon optimized cDNA(gene) Clone

Mnar Cat #

RPY2346

Tag

Mnar contains A 6x histidine tag

Mnar Formulation

Liquid

Mnar Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Mnar Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Mnar Protein

Mnar Cat #

PY2346

Mnar Source

recombinant

Mnar Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Mnar Purity

>90%, as determined by SDS-PAGE under reducing conditions

Mnar Activity

N/A

Tag

Mnar Contains A 6x histidine tag

Mnar Formulation

Liquid

Mnar Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Mnar family

-

Mnar Subcellular locations

Nucleus. Cytoplasm.

Mnar FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulates E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K (By similarity).

Mnar Sequence

DDBJ

EMBL

GenBank

Mnar 3D structure

ModBase

Mnar interaction

STRING

Mnar Proteomic

PRIDE

Mnar Genome annotation

Ensembl

GeneID

KEGG

UCSC

Mnar Organism specific

CTD

MGI

Mnar Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Mnar Gene expression

Bgee

ArrayExpress

Genevestigator

Mnar Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY