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Human Proline- glutamic acid- leucine-rich protein 1 (aa 1-1130 )

HMX3 Swiss Prot#

Q8IZL8

HMX3 Protein names

Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)

HMX3 Gene names

PELP1 HMX3 MNAR

Organism

Homo sapiens (Human)

HMX3 Entry name

PELP1_HUMAN

HMX3 Codon optimized cDNA(gene) Clone

HMX3 Cat #

RPY2345

Tag

HMX3 contains A 6x histidine tag

HMX3 Formulation

Liquid

HMX3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HMX3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HMX3 Protein

HMX3 Cat #

PY2345

HMX3 Source

recombinant

HMX3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HMX3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

HMX3 Activity

N/A

Tag

HMX3 Contains A 6x histidine tag

HMX3 Formulation

Liquid

HMX3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HMX3 family

-

HMX3 Subcellular locations

Nucleus. Cytoplasm.

HMX3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.

HMX3 Sequence

DDBJ

EMBL

GenBank

HMX3 3D structure

ModBase

HMX3 interaction

STRING

HMX3 Proteomic

PRIDE

HMX3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

HMX3 Organism specific

CTD

MGI

HMX3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HMX3 Gene expression

Bgee

ArrayExpress

Genevestigator

HMX3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY