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Human Huntingtin-interacting protein 1 (aa 1-1037 )

HIP1 Swiss Prot#

O00291

HIP1 Protein names

Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)

HIP1 Gene names

HIP1

Organism

Homo sapiens (Human)

HIP1 Entry name

HIP1_HUMAN

HIP1 Codon optimized cDNA(gene) Clone

HIP1 Cat #

RPY2256

Tag

HIP1 contains A 6x histidine tag

HIP1 Formulation

Liquid

HIP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HIP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HIP1 Protein

HIP1 Cat #

PY2256

HIP1 Source

recombinant

HIP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HIP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

HIP1 Activity

N/A

Tag

HIP1 Contains A 6x histidine tag

HIP1 Formulation

Liquid

HIP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HIP1 family

SLA2 family

HIP1 Subcellular locations

Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane.

HIP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

HIP1 Sequence

DDBJ

EMBL

GenBank

HIP1 3D structure

ModBase

HIP1 interaction

STRING

HIP1 Proteomic

PRIDE

HIP1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

HIP1 Organism specific

CTD

MGI

HIP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HIP1 Gene expression

Bgee

ArrayExpress

Genevestigator

HIP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY