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Rat Myosin phosphatase Rho-interacting protein (aa 1-1029 )

Mrip Swiss Prot#

Q9ERE6

Mrip Protein names

Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (RIP3) (p116Rip)

Mrip Gene names

Mprip Mrip Rhoip3

Organism

Rattus norvegicus (Rat)

Mrip Entry name

MPRIP_RAT

Mrip Codon optimized cDNA(gene) Clone

Mrip Cat #

RPY2247

Tag

Mrip contains A 6x histidine tag

Mrip Formulation

Liquid

Mrip Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Mrip Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Mrip Protein

Mrip Cat #

PY2247

Mrip Source

recombinant

Mrip Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Mrip Purity

>90%, as determined by SDS-PAGE under reducing conditions

Mrip Activity

N/A

Tag

Mrip Contains A 6x histidine tag

Mrip Formulation

Liquid

Mrip Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Mrip family

-

Mrip Subcellular locations

Cytoplasm > cytoskeleton.

Mrip FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells (By similarity).

Mrip Sequence

DDBJ

EMBL

GenBank

Mrip 3D structure

ModBase

Mrip interaction

STRING

Mrip Proteomic

PRIDE

Mrip Genome annotation

Ensembl

GeneID

KEGG

UCSC

Mrip Organism specific

CTD

MGI

Mrip Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Mrip Gene expression

Bgee

ArrayExpress

Genevestigator

Mrip Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY