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Human Myosin phosphatase Rho-interacting protein (aa 1-1025 )

MPRIP Swiss Prot#

Q6WCQ1

MPRIP Protein names

Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)

MPRIP Gene names

MPRIP KIAA0864 MRIP RHOIP3

Organism

Homo sapiens (Human)

MPRIP Entry name

MPRIP_HUMAN

MPRIP Codon optimized cDNA(gene) Clone

MPRIP Cat #

RPY2239

Tag

MPRIP contains A 6x histidine tag

MPRIP Formulation

Liquid

MPRIP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MPRIP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MPRIP Protein

MPRIP Cat #

PY2239

MPRIP Source

recombinant

MPRIP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MPRIP Purity

>90%, as determined by SDS-PAGE under reducing conditions

MPRIP Activity

N/A

Tag

MPRIP Contains A 6x histidine tag

MPRIP Formulation

Liquid

MPRIP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MPRIP family

-

MPRIP Subcellular locations

Cytoplasm > cytoskeleton.

MPRIP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

MPRIP Sequence

DDBJ

EMBL

GenBank

MPRIP 3D structure

ModBase

MPRIP interaction

STRING

MPRIP Proteomic

PRIDE

MPRIP Genome annotation

Ensembl

GeneID

KEGG

UCSC

MPRIP Organism specific

CTD

MGI

MPRIP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MPRIP Gene expression

Bgee

ArrayExpress

Genevestigator

MPRIP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY