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Human Rho guanine nucleotide exchange factor 2 (aa 1-986 )

ARHGEF2 Swiss Prot#

Q92974

ARHGEF2 Protein names

Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)

ARHGEF2 Gene names

ARHGEF2 KIAA0651 LFP40

Organism

Homo sapiens (Human)

ARHGEF2 Entry name

ARHG2_HUMAN

ARHGEF2 Codon optimized cDNA(gene) Clone

ARHGEF2 Cat #

RPY2204

Tag

ARHGEF2 contains A 6x histidine tag

ARHGEF2 Formulation

Liquid

ARHGEF2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARHGEF2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARHGEF2 Protein

ARHGEF2 Cat #

PY2204

ARHGEF2 Source

recombinant

ARHGEF2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARHGEF2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARHGEF2 Activity

N/A

Tag

ARHGEF2 Contains A 6x histidine tag

ARHGEF2 Formulation

Liquid

ARHGEF2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARHGEF2 family

-

ARHGEF2 Subcellular locations

Cytoplasm. Cell junction > tight junction. Golgi apparatus. Cytoplasm > cytoskeleton > spindle. Cell projection > ruffle membrane.

ARHGEF2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.

ARHGEF2 Sequence

DDBJ

EMBL

GenBank

ARHGEF2 3D structure

ModBase

ARHGEF2 interaction

STRING

ARHGEF2 Proteomic

PRIDE

ARHGEF2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARHGEF2 Organism specific

CTD

MGI

ARHGEF2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARHGEF2 Gene expression

Bgee

ArrayExpress

Genevestigator

ARHGEF2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY