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Rat Ubiquitin carboxyl-terminal hydrolase CYLD (aa 1-953 )

Cyld1 Swiss Prot#

Q66H62

Cyld1 Protein names

Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thiolesterase CYLD) (Ubiquitin-specific-processing protease CYLD)

Cyld1 Gene names

Cyld Cyld1

Organism

Rattus norvegicus (Rat)

Cyld1 Entry name

CYLD_RAT

Cyld1 Codon optimized cDNA(gene) Clone

Cyld1 Cat #

RPY2155

Tag

Cyld1 contains A 6x histidine tag

Cyld1 Formulation

Liquid

Cyld1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cyld1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cyld1 Protein

Cyld1 Cat #

PY2155

Cyld1 Source

recombinant

Cyld1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cyld1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cyld1 Activity

N/A

Tag

Cyld1 Contains A 6x histidine tag

Cyld1 Formulation

Liquid

Cyld1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cyld1 family

Peptidase C67 family

Cyld1 Subcellular locations

Cytoplasm. Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Cyld1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity).

Cyld1 Sequence

DDBJ

EMBL

GenBank

Cyld1 3D structure

ModBase

Cyld1 interaction

STRING

Cyld1 Proteomic

PRIDE

Cyld1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cyld1 Organism specific

CTD

MGI

Cyld1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cyld1 Gene expression

Bgee

ArrayExpress

Genevestigator

Cyld1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY