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Human Dystroglycan (aa 1-895 )

DAG1 Swiss Prot#

Q14118

DAG1 Protein names

Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]

DAG1 Gene names

DAG1

Organism

Homo sapiens (Human)

DAG1 Entry name

DAG1_HUMAN

DAG1 Codon optimized cDNA(gene) Clone

DAG1 Cat #

RPY2085

Tag

DAG1 contains A 6x histidine tag

DAG1 Formulation

Liquid

DAG1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DAG1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DAG1 Protein

DAG1 Cat #

PY2085

DAG1 Source

recombinant

DAG1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DAG1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DAG1 Activity

N/A

Tag

DAG1 Contains A 6x histidine tag

DAG1 Formulation

Liquid

DAG1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DAG1 family

-

DAG1 Subcellular locations

Secreted > extracellular space. Cell membrane; Single-pass type I membrane protein. Cytoplasm > cytoskeleton. Nucleus > nucleoplasm.

DAG1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.; FUNCTION: Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

DAG1 Sequence

DDBJ

EMBL

GenBank

DAG1 3D structure

ModBase

DAG1 interaction

STRING

DAG1 Proteomic

PRIDE

DAG1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DAG1 Organism specific

CTD

MGI

DAG1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DAG1 Gene expression

Bgee

ArrayExpress

Genevestigator

DAG1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY