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Human Cadherin-1 (aa 1-882 )
CDHE Swiss Prot#
P12830
CDHE Protein names
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
CDHE Gene names
CDH1 CDHE UVO
Organism
Homo sapiens (Human)
CDHE Entry name
CADH1_HUMAN
CDHE Codon optimized cDNA(gene) Clone
CDHE Cat #
RPY2070
Tag
CDHE contains A 6x histidine tag
CDHE Formulation
Liquid
CDHE Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
CDHE Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant CDHE Protein
CDHE Cat #
PY2070
CDHE Source
recombinant
CDHE Applications
Western Blot, SDS-Page or may be used for other applications determined by user
CDHE Purity
>90%, as determined by SDS-PAGE under reducing conditions
CDHE Activity
N/A
Tag
CDHE Contains A 6x histidine tag
CDHE Formulation
Liquid
CDHE Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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CDHE family
-
CDHE Subcellular locations
Cell junction. Cell membrane; Single-pass type I membrane protein.
CDHE FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
CDHE Sequence
DDBJ EMBL GenBank
CDHE 3D structure
ModBase
CDHE interaction
STRING
CDHE Proteomic
PRIDE
CDHE Genome annotation
Ensembl GeneID KEGG UCSC
CDHE Organism specific
CTD MGI
CDHE Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CDHE Gene expression
Bgee ArrayExpress Genevestigator
CDHE Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY