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| Human Cadherin-1 (aa 1-882 ) |
| CDHE Swiss Prot# | | P12830 |
| CDHE Protein names | | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] |
| CDHE Gene names | | CDH1 CDHE UVO |
| Organism | | Homo sapiens (Human) |
| CDHE Entry name | | CADH1_HUMAN |
| CDHE Codon optimized cDNA(gene) Clone |
| CDHE Cat # | | RPY2070 |
| Tag | | CDHE contains A 6x histidine tag |
| CDHE Formulation | | Liquid |
| CDHE Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CDHE Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CDHE Protein |
| CDHE Cat # | | PY2070 |
| CDHE Source | | recombinant |
| CDHE Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CDHE Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CDHE Activity | | N/A |
| Tag | | CDHE Contains A 6x histidine tag |
| CDHE Formulation | | Liquid |
| CDHE Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CDHE Products | | For pricing and availability Click Here >>> |
| CDHE family | | - |
| CDHE Subcellular locations | | Cell junction. Cell membrane; Single-pass type I membrane protein. |
| CDHE FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. |
| CDHE Sequence | | DDBJ | EMBL | GenBank |
| CDHE 3D structure | | ModBase |
| CDHE interaction | | STRING |
| CDHE Proteomic | | PRIDE |
| CDHE Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CDHE Organism specific | | CTD | MGI |
| CDHE Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CDHE Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CDHE Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |