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Mouse Programmed cell death 6-interacting protein (aa 1-869 )

Aip1 Swiss Prot#

Q9WU78

Aip1 Protein names

Programmed cell death 6-interacting protein (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (E2F1-inducible protein) (Eig2)

Aip1 Gene names

Pdcd6ip Aip1 Alix

Organism

Mus musculus (Mouse)

Aip1 Entry name

PDC6I_MOUSE

Aip1 Codon optimized cDNA(gene) Clone

Aip1 Cat #

RPY2047

Tag

Aip1 contains A 6x histidine tag

Aip1 Formulation

Liquid

Aip1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Aip1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Aip1 Protein

Aip1 Cat #

PY2047

Aip1 Source

recombinant

Aip1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Aip1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Aip1 Activity

N/A

Tag

Aip1 Contains A 6x histidine tag

Aip1 Formulation

Liquid

Aip1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Aip1 family

-

Aip1 Subcellular locations

Cytoplasm > cytosol. Melanosome. Cytoplasm > cytoskeleton > centrosome.

Aip1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation.

Aip1 Sequence

DDBJ

EMBL

GenBank

Aip1 3D structure

ModBase

Aip1 interaction

STRING

Aip1 Proteomic

PRIDE

Aip1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Aip1 Organism specific

CTD

MGI

Aip1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Aip1 Gene expression

Bgee

ArrayExpress

Genevestigator

Aip1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY