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Rat Disrupted in schizophrenia 1 homolog (aa 1-846 )

Disc1 Swiss Prot#

Q810H6

Disc1 Protein names

Disrupted in schizophrenia 1 homolog

Disc1 Gene names

Disc1

Organism

Rattus norvegicus (Rat)

Disc1 Entry name

DISC1_RAT

Disc1 Codon optimized cDNA(gene) Clone

Disc1 Cat #

RPY2010

Tag

Disc1 contains A 6x histidine tag

Disc1 Formulation

Liquid

Disc1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Disc1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Disc1 Protein

Disc1 Cat #

PY2010

Disc1 Source

recombinant

Disc1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Disc1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Disc1 Activity

N/A

Tag

Disc1 Contains A 6x histidine tag

Disc1 Formulation

Liquid

Disc1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Disc1 family

-

Disc1 Subcellular locations

Cytoplasm > cytoskeleton > centrosome. Cytoplasm. Cytoplasm > cytoskeleton.

Disc1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Disc1 Sequence

DDBJ

EMBL

GenBank

Disc1 3D structure

ModBase

Disc1 interaction

STRING

Disc1 Proteomic

PRIDE

Disc1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Disc1 Organism specific

CTD

MGI

Disc1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Disc1 Gene expression

Bgee

ArrayExpress

Genevestigator

Disc1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY