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Human E3 ubiquitin-protein ligase RNF19A (aa 1-838 )

RNF19 Swiss Prot#

Q9NV58

RNF19 Protein names

E3 ubiquitin-protein ligase RNF19A (EC 6.3.2.-) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)

RNF19 Gene names

RNF19A RNF19

Organism

Homo sapiens (Human)

RNF19 Entry name

RN19A_HUMAN

RNF19 Codon optimized cDNA(gene) Clone

RNF19 Cat #

RPY1999

Tag

RNF19 contains A 6x histidine tag

RNF19 Formulation

Liquid

RNF19 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RNF19 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RNF19 Protein

RNF19 Cat #

PY1999

RNF19 Source

recombinant

RNF19 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RNF19 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RNF19 Activity

N/A

Tag

RNF19 Contains A 6x histidine tag

RNF19 Formulation

Liquid

RNF19 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RNF19 family

RBR family, RNF19 subfamily

RNF19 Subcellular locations

Membrane; Multi-pass membrane protein. Cytoplasm > cytoskeleton > centrosome.

RNF19 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

RNF19 Sequence

DDBJ

EMBL

GenBank

RNF19 3D structure

ModBase

RNF19 interaction

STRING

RNF19 Proteomic

PRIDE

RNF19 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RNF19 Organism specific

CTD

MGI

RNF19 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RNF19 Gene expression

Bgee

ArrayExpress

Genevestigator

RNF19 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY