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Human Enhancer filamentation 1 (aa 1-834 )

CASL Swiss Prot#

Q14511

CASL Protein names

Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]

CASL Gene names

NEDD9 CASL CASS2

Organism

Homo sapiens (Human)

CASL Entry name

CASL_HUMAN

CASL Codon optimized cDNA(gene) Clone

CASL Cat #

RPY1994

Tag

CASL contains A 6x histidine tag

CASL Formulation

Liquid

CASL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CASL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CASL Protein

CASL Cat #

PY1994

CASL Source

recombinant

CASL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CASL Purity

>90%, as determined by SDS-PAGE under reducing conditions

CASL Activity

N/A

Tag

CASL Contains A 6x histidine tag

CASL Formulation

Liquid

CASL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CASL family

CAS family

CASL Subcellular locations

Cytoplasm > cell cortex. Nucleus. Golgi apparatus. Cell projection > lamellipodium. Cytoplasm. Cell junction > focal adhesion. Cytoplasm > cytoskeleton > spindle.

CASL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

CASL Sequence

DDBJ

EMBL

GenBank

CASL 3D structure

ModBase

CASL interaction

STRING

CASL Proteomic

PRIDE

CASL Genome annotation

Ensembl

GeneID

KEGG

UCSC

CASL Organism specific

CTD

MGI

CASL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CASL Gene expression

Bgee

ArrayExpress

Genevestigator

CASL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY