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Human Disintegrin metalloproteinase domain-containing 17 (aa 1-824 )

CSVP Swiss Prot#

P78536

CSVP Protein names

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)

CSVP Gene names

ADAM17 CSVP TACE

Organism

Homo sapiens (Human)

CSVP Entry name

ADA17_HUMAN

CSVP Codon optimized cDNA(gene) Clone

CSVP Cat #

RPY1972

Tag

CSVP contains A 6x histidine tag

CSVP Formulation

Liquid

CSVP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CSVP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CSVP Protein

CSVP Cat #

PY1972

CSVP Source

recombinant

CSVP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CSVP Purity

>90%, as determined by SDS-PAGE under reducing conditions

CSVP Activity

N/A

Tag

CSVP Contains A 6x histidine tag

CSVP Formulation

Liquid

CSVP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CSVP family

-

CSVP Subcellular locations

Membrane; Single-pass type I membrane protein.

CSVP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).

CSVP Sequence

DDBJ

EMBL

GenBank

CSVP 3D structure

ModBase

CSVP interaction

STRING

CSVP Proteomic

PRIDE

CSVP Genome annotation

Ensembl

GeneID

KEGG

UCSC

CSVP Organism specific

CTD

MGI

CSVP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CSVP Gene expression

Bgee

ArrayExpress

Genevestigator

CSVP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY