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Rat Neurabin-2 (aa 1-817 )

Ppp1r9b Swiss Prot#

O35274

Ppp1r9b Protein names

Neurabin-2 (Neurabin-II) (Neural tissue-specific F-actin-binding protein II) (PP1bp134) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) (p130)

Ppp1r9b Gene names

Ppp1r9b

Organism

Rattus norvegicus (Rat)

Ppp1r9b Entry name

NEB2_RAT

Ppp1r9b Codon optimized cDNA(gene) Clone

Ppp1r9b Cat #

RPY1960

Tag

Ppp1r9b contains A 6x histidine tag

Ppp1r9b Formulation

Liquid

Ppp1r9b Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ppp1r9b Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ppp1r9b Protein

Ppp1r9b Cat #

PY1960

Ppp1r9b Source

recombinant

Ppp1r9b Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ppp1r9b Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ppp1r9b Activity

N/A

Tag

Ppp1r9b Contains A 6x histidine tag

Ppp1r9b Formulation

Liquid

Ppp1r9b Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ppp1r9b family

-

Ppp1r9b Subcellular locations

Cytoplasm > cytoskeleton. Nucleus. Cell junction > synapse. Cell junction > adherens junction. Cell projection > dendritic spine.

Ppp1r9b FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1.

Ppp1r9b Sequence

DDBJ

EMBL

GenBank

Ppp1r9b 3D structure

ModBase

Ppp1r9b interaction

STRING

Ppp1r9b Proteomic

PRIDE

Ppp1r9b Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ppp1r9b Organism specific

CTD

MGI

Ppp1r9b Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ppp1r9b Gene expression

Bgee

ArrayExpress

Genevestigator

Ppp1r9b Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY