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Human Neurabin-2 (aa 1-815 )

PPP1R6 Swiss Prot#

Q96SB3

PPP1R6 Protein names

Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)

PPP1R6 Gene names

PPP1R9B PPP1R6

Organism

Homo sapiens (Human)

PPP1R6 Entry name

NEB2_HUMAN

PPP1R6 Codon optimized cDNA(gene) Clone

PPP1R6 Cat #

RPY1956

Tag

PPP1R6 contains A 6x histidine tag

PPP1R6 Formulation

Liquid

PPP1R6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PPP1R6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PPP1R6 Protein

PPP1R6 Cat #

PY1956

PPP1R6 Source

recombinant

PPP1R6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PPP1R6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PPP1R6 Activity

N/A

Tag

PPP1R6 Contains A 6x histidine tag

PPP1R6 Formulation

Liquid

PPP1R6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PPP1R6 family

-

PPP1R6 Subcellular locations

Cytoplasm > cytoskeleton. Nucleus. Cell projection > dendritic spine. Cell junction > synapse.

PPP1R6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity).

PPP1R6 Sequence

DDBJ

EMBL

GenBank

PPP1R6 3D structure

ModBase

PPP1R6 interaction

STRING

PPP1R6 Proteomic

PRIDE

PPP1R6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PPP1R6 Organism specific

CTD

MGI

PPP1R6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PPP1R6 Gene expression

Bgee

ArrayExpress

Genevestigator

PPP1R6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY