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Human Ubiquitin carboxyl-terminal hydrolase 10 (aa 1-798 )

USP10 Swiss Prot#

Q14694

USP10 Protein names

Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thiolesterase 10) (Ubiquitin-specific-processing protease 10)

USP10 Gene names

USP10 KIAA0190

Organism

Homo sapiens (Human)

USP10 Entry name

UBP10_HUMAN

USP10 Codon optimized cDNA(gene) Clone

USP10 Cat #

RPY1929

Tag

USP10 contains A 6x histidine tag

USP10 Formulation

Liquid

USP10 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

USP10 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant USP10 Protein

USP10 Cat #

PY1929

USP10 Source

recombinant

USP10 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

USP10 Purity

>90%, as determined by SDS-PAGE under reducing conditions

USP10 Activity

N/A

Tag

USP10 Contains A 6x histidine tag

USP10 Formulation

Liquid

USP10 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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USP10 family

Peptidase C19 family, USP10 subfamily

USP10 Subcellular locations

Cytoplasm. Nucleus. Early endosome.

USP10 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.

USP10 Sequence

DDBJ

EMBL

GenBank

USP10 3D structure

ModBase

USP10 interaction

STRING

USP10 Proteomic

PRIDE

USP10 Genome annotation

Ensembl

GeneID

KEGG

UCSC

USP10 Organism specific

CTD

MGI

USP10 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

USP10 Gene expression

Bgee

ArrayExpress

Genevestigator

USP10 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY