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Human Pleckstrin homology domain-containing family G 6 (aa 1-790 )
PLEKHG6 Swiss Prot#
Q3KR16
PLEKHG6 Protein names
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
PLEKHG6 Gene names
PLEKHG6
Organism
Homo sapiens (Human)
PLEKHG6 Entry name
PKHG6_HUMAN
PLEKHG6 Codon optimized cDNA(gene) Clone
PLEKHG6 Cat #
RPY1917
Tag
PLEKHG6 contains A 6x histidine tag
PLEKHG6 Formulation
Liquid
PLEKHG6 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
PLEKHG6 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant PLEKHG6 Protein
PLEKHG6 Cat #
PY1917
PLEKHG6 Source
recombinant
PLEKHG6 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
PLEKHG6 Purity
>90%, as determined by SDS-PAGE under reducing conditions
PLEKHG6 Activity
N/A
Tag
PLEKHG6 Contains A 6x histidine tag
PLEKHG6 Formulation
Liquid
PLEKHG6 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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PLEKHG6 family
-
PLEKHG6 Subcellular locations
Cytoplasm. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Cleavage furrow.
PLEKHG6 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
PLEKHG6 Sequence
DDBJ EMBL GenBank
PLEKHG6 3D structure
ModBase
PLEKHG6 interaction
STRING
PLEKHG6 Proteomic
PRIDE
PLEKHG6 Genome annotation
Ensembl GeneID KEGG UCSC
PLEKHG6 Organism specific
CTD MGI
PLEKHG6 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PLEKHG6 Gene expression
Bgee ArrayExpress Genevestigator
PLEKHG6 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY