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Human Microprocessor complex subunit DGCR8 (aa 1-773 )

C22orf12 Swiss Prot#

Q8WYQ5

C22orf12 Protein names

Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)

C22orf12 Gene names

DGCR8 C22orf12 DGCRK6 LP4941

Organism

Homo sapiens (Human)

C22orf12 Entry name

DGCR8_HUMAN

C22orf12 Codon optimized cDNA(gene) Clone

C22orf12 Cat #

RPY1883

Tag

C22orf12 contains A 6x histidine tag

C22orf12 Formulation

Liquid

C22orf12 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

C22orf12 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant C22orf12 Protein

C22orf12 Cat #

PY1883

C22orf12 Source

recombinant

C22orf12 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

C22orf12 Purity

>90%, as determined by SDS-PAGE under reducing conditions

C22orf12 Activity

N/A

Tag

C22orf12 Contains A 6x histidine tag

C22orf12 Formulation

Liquid

C22orf12 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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C22orf12 family

-

C22orf12 Subcellular locations

Nucleus. Nucleus > nucleolus.

C22orf12 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.

C22orf12 Sequence

DDBJ

EMBL

GenBank

C22orf12 3D structure

ModBase

C22orf12 interaction

STRING

C22orf12 Proteomic

PRIDE

C22orf12 Genome annotation

Ensembl

GeneID

KEGG

UCSC

C22orf12 Organism specific

CTD

MGI

C22orf12 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

C22orf12 Gene expression

Bgee

ArrayExpress

Genevestigator

C22orf12 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY