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Human TFIIH basal transcription factor complex helicase XPD (aa 1-760 )

XPD Swiss Prot#

P18074

XPD Protein names

TFIIH basal transcription factor complex helicase XPD subunit (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)

XPD Gene names

ERCC2 XPD XPDC

Organism

Homo sapiens (Human)

XPD Entry name

ERCC2_HUMAN

XPD Codon optimized cDNA(gene) Clone

XPD Cat #

RPY1871

Tag

XPD contains A 6x histidine tag

XPD Formulation

Liquid

XPD Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

XPD Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant XPD Protein

XPD Cat #

PY1871

XPD Source

recombinant

XPD Applications

Western Blot, SDS-Page or may be used for other applications determined by user

XPD Purity

>90%, as determined by SDS-PAGE under reducing conditions

XPD Activity

N/A

Tag

XPD Contains A 6x histidine tag

XPD Formulation

Liquid

XPD Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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XPD family

Helicase family, RAD3/XPD subfamily

XPD Subcellular locations

Nucleus. Cytoplasm > cytoskeleton > spindle.

XPD FUNCTION According to UniProtKB Swiss Prot

FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

XPD Sequence

DDBJ

EMBL

GenBank

XPD 3D structure

ModBase

XPD interaction

STRING

XPD Proteomic

PRIDE

XPD Genome annotation

Ensembl

GeneID

KEGG

UCSC

XPD Organism specific

CTD

MGI

XPD Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

XPD Gene expression

Bgee

ArrayExpress

Genevestigator

XPD Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY