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Human Microtubule-associated protein tau (aa 1-758 )

MAPTL Swiss Prot#

P10636

MAPTL Protein names

Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

MAPTL Gene names

MAPT MAPTL MTBT1 TAU

Organism

Homo sapiens (Human)

MAPTL Entry name

TAU_HUMAN

MAPTL Codon optimized cDNA(gene) Clone

MAPTL Cat #

RPY1868

Tag

MAPTL contains A 6x histidine tag

MAPTL Formulation

Liquid

MAPTL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MAPTL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MAPTL Protein

MAPTL Cat #

PY1868

MAPTL Source

recombinant

MAPTL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MAPTL Purity

>90%, as determined by SDS-PAGE under reducing conditions

MAPTL Activity

N/A

Tag

MAPTL Contains A 6x histidine tag

MAPTL Formulation

Liquid

MAPTL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MAPTL family

-

MAPTL Subcellular locations

Cytoplasm > cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm > cytoskeleton. Cell projection > axon.

MAPTL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

MAPTL Sequence

DDBJ

EMBL

GenBank

MAPTL 3D structure

ModBase

MAPTL interaction

STRING

MAPTL Proteomic

PRIDE

MAPTL Genome annotation

Ensembl

GeneID

KEGG

UCSC

MAPTL Organism specific

CTD

MGI

MAPTL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MAPTL Gene expression

Bgee

ArrayExpress

Genevestigator

MAPTL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY