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Human Rho GTPase-activating protein 24 (aa 1-748 )

FILGAP Swiss Prot#

Q8N264

FILGAP Protein names

Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)

FILGAP Gene names

ARHGAP24 FILGAP

Organism

Homo sapiens (Human)

FILGAP Entry name

RHG24_HUMAN

FILGAP Codon optimized cDNA(gene) Clone

FILGAP Cat #

RPY1850

Tag

FILGAP contains A 6x histidine tag

FILGAP Formulation

Liquid

FILGAP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FILGAP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FILGAP Protein

FILGAP Cat #

PY1850

FILGAP Source

recombinant

FILGAP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FILGAP Purity

>90%, as determined by SDS-PAGE under reducing conditions

FILGAP Activity

N/A

Tag

FILGAP Contains A 6x histidine tag

FILGAP Formulation

Liquid

FILGAP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FILGAP family

-

FILGAP Subcellular locations

Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell junction > focal adhesion. Cell projection.

FILGAP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

FILGAP Sequence

DDBJ

EMBL

GenBank

FILGAP 3D structure

ModBase

FILGAP interaction

STRING

FILGAP Proteomic

PRIDE

FILGAP Genome annotation

Ensembl

GeneID

KEGG

UCSC

FILGAP Organism specific

CTD

MGI

FILGAP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FILGAP Gene expression

Bgee

ArrayExpress

Genevestigator

FILGAP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY