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Mouse Junction plakoglobin (aa 1-745 )

Jup Swiss Prot#

Q02257

Jup Protein names

Junction plakoglobin (Desmoplakin III) (Desmoplakin-3)

Jup Gene names

Jup

Organism

Mus musculus (Mouse)

Jup Entry name

PLAK_MOUSE

Jup Codon optimized cDNA(gene) Clone

Jup Cat #

RPY1839

Tag

Jup contains A 6x histidine tag

Jup Formulation

Liquid

Jup Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Jup Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Jup Protein

Jup Cat #

PY1839

Jup Source

recombinant

Jup Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Jup Purity

>90%, as determined by SDS-PAGE under reducing conditions

Jup Activity

N/A

Tag

Jup Contains A 6x histidine tag

Jup Formulation

Liquid

Jup Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Jup family

Beta-catenin family

Jup Subcellular locations

Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane; Peripheral membrane protein.

Jup FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Jup Sequence

DDBJ

EMBL

GenBank

Jup 3D structure

ModBase

Jup interaction

STRING

Jup Proteomic

PRIDE

Jup Genome annotation

Ensembl

GeneID

KEGG

UCSC

Jup Organism specific

CTD

MGI

Jup Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Jup Gene expression

Bgee

ArrayExpress

Genevestigator

Jup Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY