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Human Nephrocystin-1 (aa 1-732 )

NPH1 Swiss Prot#

O15259

NPH1 Protein names

Nephrocystin-1 (Juvenile nephronophthisis 1 protein)

NPH1 Gene names

NPHP1 NPH1

Organism

Homo sapiens (Human)

NPH1 Entry name

NPHP1_HUMAN

NPH1 Codon optimized cDNA(gene) Clone

NPH1 Cat #

RPY1811

Tag

NPH1 contains A 6x histidine tag

NPH1 Formulation

Liquid

NPH1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NPH1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NPH1 Protein

NPH1 Cat #

PY1811

NPH1 Source

recombinant

NPH1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NPH1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NPH1 Activity

N/A

Tag

NPH1 Contains A 6x histidine tag

NPH1 Formulation

Liquid

NPH1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NPH1 family

Nephrocystin-1 family

NPH1 Subcellular locations

Cell junction > adherens junction. Cell projection > cilium. Cytoplasm > cytoskeleton > cilium axoneme.

NPH1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Together with Cas it may play a role in the control of epithelial cell polarity. Seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).

NPH1 Sequence

DDBJ

EMBL

GenBank

NPH1 3D structure

ModBase

NPH1 interaction

STRING

NPH1 Proteomic

PRIDE

NPH1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NPH1 Organism specific

CTD

MGI

NPH1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NPH1 Gene expression

Bgee

ArrayExpress

Genevestigator

NPH1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY