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Human Denticleless protein homolog (aa 1-730 )

CDT2 Swiss Prot#

Q9NZJ0

CDT2 Protein names

Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)

CDT2 Gene names

DTL CDT2 CDW1 DCAF2 L2DTL RAMP

Organism

Homo sapiens (Human)

CDT2 Entry name

DTL_HUMAN

CDT2 Codon optimized cDNA(gene) Clone

CDT2 Cat #

RPY1800

Tag

CDT2 contains A 6x histidine tag

CDT2 Formulation

Liquid

CDT2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CDT2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CDT2 Protein

CDT2 Cat #

PY1800

CDT2 Source

recombinant

CDT2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CDT2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CDT2 Activity

N/A

Tag

CDT2 Contains A 6x histidine tag

CDT2 Formulation

Liquid

CDT2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CDT2 family

WD repeat cdt2 family

CDT2 Subcellular locations

Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm > cytoskeleton > centrosome.

CDT2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.

CDT2 Sequence

DDBJ

EMBL

GenBank

CDT2 3D structure

ModBase

CDT2 interaction

STRING

CDT2 Proteomic

PRIDE

CDT2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CDT2 Organism specific

CTD

MGI

CDT2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CDT2 Gene expression

Bgee

ArrayExpress

Genevestigator

CDT2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY