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Human Mitotic spindle assembly checkpoint protein MAD1 (aa 1-718 )

MAD1 Swiss Prot#

Q9Y6D9

MAD1 Protein names

Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)

MAD1 Gene names

MAD1L1 MAD1 TXBP181

Organism

Homo sapiens (Human)

MAD1 Entry name

MD1L1_HUMAN

MAD1 Codon optimized cDNA(gene) Clone

MAD1 Cat #

RPY1764

Tag

MAD1 contains A 6x histidine tag

MAD1 Formulation

Liquid

MAD1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MAD1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MAD1 Protein

MAD1 Cat #

PY1764

MAD1 Source

recombinant

MAD1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MAD1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MAD1 Activity

N/A

Tag

MAD1 Contains A 6x histidine tag

MAD1 Formulation

Liquid

MAD1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MAD1 family

MAD1 family

MAD1 Subcellular locations

Nucleus. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle.

MAD1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery.

MAD1 Sequence

DDBJ

EMBL

GenBank

MAD1 3D structure

ModBase

MAD1 interaction

STRING

MAD1 Proteomic

PRIDE

MAD1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MAD1 Organism specific

CTD

MGI

MAD1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MAD1 Gene expression

Bgee

ArrayExpress

Genevestigator

MAD1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY