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Human SUN domain-containing protein 2 (aa 1-717 )

FRIGG Swiss Prot#

Q9UH99

FRIGG Protein names

SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)

FRIGG Gene names

SUN2 FRIGG KIAA0668 RAB5IP UNC84B

Organism

Homo sapiens (Human)

FRIGG Entry name

SUN2_HUMAN

FRIGG Codon optimized cDNA(gene) Clone

FRIGG Cat #

RPY1758

Tag

FRIGG contains A 6x histidine tag

FRIGG Formulation

Liquid

FRIGG Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FRIGG Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FRIGG Protein

FRIGG Cat #

PY1758

FRIGG Source

recombinant

FRIGG Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FRIGG Purity

>90%, as determined by SDS-PAGE under reducing conditions

FRIGG Activity

N/A

Tag

FRIGG Contains A 6x histidine tag

FRIGG Formulation

Liquid

FRIGG Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FRIGG family

-

FRIGG Subcellular locations

Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.

FRIGG FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

FRIGG Sequence

DDBJ

EMBL

GenBank

FRIGG 3D structure

ModBase

FRIGG interaction

STRING

FRIGG Proteomic

PRIDE

FRIGG Genome annotation

Ensembl

GeneID

KEGG

UCSC

FRIGG Organism specific

CTD

MGI

FRIGG Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FRIGG Gene expression

Bgee

ArrayExpress

Genevestigator

FRIGG Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY