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Human Adseverin (aa 1-715 )

SCIN Swiss Prot#

Q9Y6U3

SCIN Protein names

Adseverin (Scinderin)

SCIN Gene names

SCIN KIAA1905

Organism

Homo sapiens (Human)

SCIN Entry name

ADSV_HUMAN

SCIN Codon optimized cDNA(gene) Clone

SCIN Cat #

RPY1752

Tag

SCIN contains A 6x histidine tag

SCIN Formulation

Liquid

SCIN Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SCIN Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SCIN Protein

SCIN Cat #

PY1752

SCIN Source

recombinant

SCIN Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SCIN Purity

>90%, as determined by SDS-PAGE under reducing conditions

SCIN Activity

N/A

Tag

SCIN Contains A 6x histidine tag

SCIN Formulation

Liquid

SCIN Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SCIN family

Villin/gelsolin family

SCIN Subcellular locations

Cytoplasm > cytoskeleton.

SCIN FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).

SCIN Sequence

DDBJ

EMBL

GenBank

SCIN 3D structure

ModBase

SCIN interaction

STRING

SCIN Proteomic

PRIDE

SCIN Genome annotation

Ensembl

GeneID

KEGG

UCSC

SCIN Organism specific

CTD

MGI

SCIN Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SCIN Gene expression

Bgee

ArrayExpress

Genevestigator

SCIN Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY