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Human Receptor-type tyrosine-protein phosphatase epsilon (aa 1-700 )

PTPRE Swiss Prot#

P23469

PTPRE Protein names

Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)

PTPRE Gene names

PTPRE

Organism

Homo sapiens (Human)

PTPRE Entry name

PTPRE_HUMAN

PTPRE Codon optimized cDNA(gene) Clone

PTPRE Cat #

RPY1713

Tag

PTPRE contains A 6x histidine tag

PTPRE Formulation

Liquid

PTPRE Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PTPRE Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PTPRE Protein

PTPRE Cat #

PY1713

PTPRE Source

recombinant

PTPRE Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PTPRE Purity

>90%, as determined by SDS-PAGE under reducing conditions

PTPRE Activity

N/A

Tag

PTPRE Contains A 6x histidine tag

PTPRE Formulation

Liquid

PTPRE Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PTPRE family

Protein-tyrosine phosphatase family, Receptor class 4 subfamily

PTPRE Subcellular locations

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

PTPRE FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity).

PTPRE Sequence

DDBJ

EMBL

GenBank

PTPRE 3D structure

ModBase

PTPRE interaction

STRING

PTPRE Proteomic

PRIDE

PTPRE Genome annotation

Ensembl

GeneID

KEGG

UCSC

PTPRE Organism specific

CTD

MGI

PTPRE Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PTPRE Gene expression

Bgee

ArrayExpress

Genevestigator

PTPRE Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY