All rights
reserved
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||
|
|||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Human THO complex subunit 5 homolog (aa 1-683 ) |
| C22orf19 Swiss Prot# | | Q13769 |
| C22orf19 Protein names | | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) |
| C22orf19 Gene names | | THOC5 C22orf19 KIAA0983 |
| Organism | | Homo sapiens (Human) |
| C22orf19 Entry name | | THOC5_HUMAN |
| C22orf19 Codon optimized cDNA(gene) Clone |
| C22orf19 Cat # | | RPY1680 |
| Tag | | C22orf19 contains A 6x histidine tag |
| C22orf19 Formulation | | Liquid |
| C22orf19 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| C22orf19 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant C22orf19 Protein |
| C22orf19 Cat # | | PY1680 |
| C22orf19 Source | | recombinant |
| C22orf19 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| C22orf19 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| C22orf19 Activity | | N/A |
| Tag | | C22orf19 Contains A 6x histidine tag |
| C22orf19 Formulation | | Liquid |
| C22orf19 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant C22orf19 Products | | For pricing and availability Click Here >>> |
| C22orf19 family | | THOC5 family |
| C22orf19 Subcellular locations | | Nucleus. Cytoplasm. |
| C22orf19 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. |
| C22orf19 Sequence | | DDBJ | EMBL | GenBank |
| C22orf19 3D structure | | ModBase |
| C22orf19 interaction | | STRING |
| C22orf19 Proteomic | | PRIDE |
| C22orf19 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| C22orf19 Organism specific | | CTD | MGI |
| C22orf19 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| C22orf19 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| C22orf19 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
