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Mouse Prelamin-A C (aa 1-665 )

Lmn1 Swiss Prot#

P48678

Lmn1 Protein names

Prelamin-A/C [Cleaved into: Lamin-A/C]

Lmn1 Gene names

Lmna Lmn1

Organism

Mus musculus (Mouse)

Lmn1 Entry name

LMNA_MOUSE

Lmn1 Codon optimized cDNA(gene) Clone

Lmn1 Cat #

RPY1635

Tag

Lmn1 contains A 6x histidine tag

Lmn1 Formulation

Liquid

Lmn1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Lmn1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Lmn1 Protein

Lmn1 Cat #

PY1635

Lmn1 Source

recombinant

Lmn1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Lmn1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Lmn1 Activity

N/A

Tag

Lmn1 Contains A 6x histidine tag

Lmn1 Formulation

Liquid

Lmn1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Lmn1 family

Intermediate filament family

Lmn1 Subcellular locations

Nucleus. Nucleus envelope.

Lmn1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity).; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (By similarity).

Lmn1 Sequence

DDBJ

EMBL

GenBank

Lmn1 3D structure

ModBase

Lmn1 interaction

STRING

Lmn1 Proteomic

PRIDE

Lmn1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Lmn1 Organism specific

CTD

MGI

Lmn1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Lmn1 Gene expression

Bgee

ArrayExpress

Genevestigator

Lmn1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY