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Mouse Leucine-rich repeat WD repeat-containing 1 (aa 1-648 )

Orca Swiss Prot#

Q8BUI3

Orca Protein names

Leucine-rich repeat and WD repeat-containing protein 1 (ORC-associated protein) (ORCA) (Origin recognition complex-associated protein)

Orca Gene names

LRWD1 Orca

Organism

Mus musculus (Mouse)

Orca Entry name

LRWD1_MOUSE

Orca Codon optimized cDNA(gene) Clone

Orca Cat #

RPY1598

Tag

Orca contains A 6x histidine tag

Orca Formulation

Liquid

Orca Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Orca Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Orca Protein

Orca Cat #

PY1598

Orca Source

recombinant

Orca Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Orca Purity

>90%, as determined by SDS-PAGE under reducing conditions

Orca Activity

N/A

Tag

Orca Contains A 6x histidine tag

Orca Formulation

Liquid

Orca Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Orca family

LRWD1 family

Orca Subcellular locations

Nucleus. Chromosome > centromere. Chromosome > telomere. Cytoplasm > cytoskeleton > centrosome.

Orca FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors (By similarity).

Orca Sequence

DDBJ

EMBL

GenBank

Orca 3D structure

ModBase

Orca interaction

STRING

Orca Proteomic

PRIDE

Orca Genome annotation

Ensembl

GeneID

KEGG

UCSC

Orca Organism specific

CTD

MGI

Orca Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Orca Gene expression

Bgee

ArrayExpress

Genevestigator

Orca Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY