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Human Rac GTPase-activating protein 1 (aa 1-632 )

RACGAP1 Swiss Prot#

Q9H0H5

RACGAP1 Protein names

Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP)

RACGAP1 Gene names

RACGAP1 KIAA1478 MGCRACGAP

Organism

Homo sapiens (Human)

RACGAP1 Entry name

RGAP1_HUMAN

RACGAP1 Codon optimized cDNA(gene) Clone

RACGAP1 Cat #

RPY1564

Tag

RACGAP1 contains A 6x histidine tag

RACGAP1 Formulation

Liquid

RACGAP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RACGAP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RACGAP1 Protein

RACGAP1 Cat #

PY1564

RACGAP1 Source

recombinant

RACGAP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RACGAP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RACGAP1 Activity

N/A

Tag

RACGAP1 Contains A 6x histidine tag

RACGAP1 Formulation

Liquid

RACGAP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RACGAP1 family

-

RACGAP1 Subcellular locations

Nucleus. Cytoplasm. Cytoplasm > cytoskeleton > spindle. Cytoplasmic vesicle > secretory vesicle > acrosome.

RACGAP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential for the early stages of embryogenesis and may play a role in the microtubule-dependent steps in cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Required for initiation of cleavage furrow ingression by regulating ECT2 and for assembly of the contractile ring. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

RACGAP1 Sequence

DDBJ

EMBL

GenBank

RACGAP1 3D structure

ModBase

RACGAP1 interaction

STRING

RACGAP1 Proteomic

PRIDE

RACGAP1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RACGAP1 Organism specific

CTD

MGI

RACGAP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RACGAP1 Gene expression

Bgee

ArrayExpress

Genevestigator

RACGAP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY