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Mouse Rac GTPase-activating protein 1 (aa 1-628 )

Mgcracgap Swiss Prot#

Q9WVM1

Mgcracgap Protein names

Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP)

Mgcracgap Gene names

Racgap1 Mgcracgap

Organism

Mus musculus (Mouse)

Mgcracgap Entry name

RGAP1_MOUSE

Mgcracgap Codon optimized cDNA(gene) Clone

Mgcracgap Cat #

RPY1559

Tag

Mgcracgap contains A 6x histidine tag

Mgcracgap Formulation

Liquid

Mgcracgap Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Mgcracgap Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Mgcracgap Protein

Mgcracgap Cat #

PY1559

Mgcracgap Source

recombinant

Mgcracgap Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Mgcracgap Purity

>90%, as determined by SDS-PAGE under reducing conditions

Mgcracgap Activity

N/A

Tag

Mgcracgap Contains A 6x histidine tag

Mgcracgap Formulation

Liquid

Mgcracgap Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Mgcracgap family

-

Mgcracgap Subcellular locations

Nucleus. Cytoplasm. Cytoplasm > cytoskeleton > spindle. Cytoplasmic vesicle > secretory vesicle > acrosome.

Mgcracgap FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential for the early stages of embryogenesis and may play a role in the microtubule-dependent steps in cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Required for initiation of cleavage furrow ingression by regulating ECT2 and for assembly of the contractile ring. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

Mgcracgap Sequence

DDBJ

EMBL

GenBank

Mgcracgap 3D structure

ModBase

Mgcracgap interaction

STRING

Mgcracgap Proteomic

PRIDE

Mgcracgap Genome annotation

Ensembl

GeneID

KEGG

UCSC

Mgcracgap Organism specific

CTD

MGI

Mgcracgap Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Mgcracgap Gene expression

Bgee

ArrayExpress

Genevestigator

Mgcracgap Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY