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Mouse SH2B adapter protein 2 (aa 1-621 )

Aps Swiss Prot#

Q9JID9

Aps Protein names

SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)

Aps Gene names

Sh2b2 Aps

Organism

Mus musculus (Mouse)

Aps Entry name

SH2B2_MOUSE

Aps Codon optimized cDNA(gene) Clone

Aps Cat #

RPY1544

Tag

Aps contains A 6x histidine tag

Aps Formulation

Liquid

Aps Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Aps Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Aps Protein

Aps Cat #

PY1544

Aps Source

recombinant

Aps Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Aps Purity

>90%, as determined by SDS-PAGE under reducing conditions

Aps Activity

N/A

Tag

Aps Contains A 6x histidine tag

Aps Formulation

Liquid

Aps Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Aps family

SH2B adapter family

Aps Subcellular locations

Cytoplasm. Cell membrane.

Aps FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).

Aps Sequence

DDBJ

EMBL

GenBank

Aps 3D structure

ModBase

Aps interaction

STRING

Aps Proteomic

PRIDE

Aps Genome annotation

Ensembl

GeneID

KEGG

UCSC

Aps Organism specific

CTD

MGI

Aps Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Aps Gene expression

Bgee

ArrayExpress

Genevestigator

Aps Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY