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Rat Formin-binding protein 1 (aa 1-616 )

Fbp17 Swiss Prot#

Q8R511

Fbp17 Protein names

Formin-binding protein 1 (Formin-binding protein 17) (Rapostlin)

Fbp17 Gene names

Fnbp1 Fbp17

Organism

Rattus norvegicus (Rat)

Fbp17 Entry name

FNBP1_RAT

Fbp17 Codon optimized cDNA(gene) Clone

Fbp17 Cat #

RPY1529

Tag

Fbp17 contains A 6x histidine tag

Fbp17 Formulation

Liquid

Fbp17 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Fbp17 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Fbp17 Protein

Fbp17 Cat #

PY1529

Fbp17 Source

recombinant

Fbp17 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Fbp17 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Fbp17 Activity

N/A

Tag

Fbp17 Contains A 6x histidine tag

Fbp17 Formulation

Liquid

Fbp17 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Fbp17 family

FNBP1 family

Fbp17 Subcellular locations

Cytoplasm > cell cortex. Cytoplasm. Cytoplasmic vesicle. Lysosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm > cytoskeleton.

Fbp17 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By similarity). May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells.

Fbp17 Sequence

DDBJ

EMBL

GenBank

Fbp17 3D structure

ModBase

Fbp17 interaction

STRING

Fbp17 Proteomic

PRIDE

Fbp17 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Fbp17 Organism specific

CTD

MGI

Fbp17 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Fbp17 Gene expression

Bgee

ArrayExpress

Genevestigator

Fbp17 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY