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Human Spastin (aa 1-616 )

ADPSP Swiss Prot#

Q9UBP0

ADPSP Protein names

Spastin (EC 3.6.4.3) (Spastic paraplegia 4 protein)

ADPSP Gene names

SPAST ADPSP FSP2 KIAA1083 SPG4

Organism

Homo sapiens (Human)

ADPSP Entry name

SPAST_HUMAN

ADPSP Codon optimized cDNA(gene) Clone

ADPSP Cat #

RPY1526

Tag

ADPSP contains A 6x histidine tag

ADPSP Formulation

Liquid

ADPSP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ADPSP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ADPSP Protein

ADPSP Cat #

PY1526

ADPSP Source

recombinant

ADPSP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ADPSP Purity

>90%, as determined by SDS-PAGE under reducing conditions

ADPSP Activity

N/A

Tag

ADPSP Contains A 6x histidine tag

ADPSP Formulation

Liquid

ADPSP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ADPSP family

AAA ATPase family, Spastin subfamily

ADPSP Subcellular locations

Membrane; Single-pass membrane protein. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm > cytoskeleton > spindle.

ADPSP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches.

ADPSP Sequence

DDBJ

EMBL

GenBank

ADPSP 3D structure

ModBase

ADPSP interaction

STRING

ADPSP Proteomic

PRIDE

ADPSP Genome annotation

Ensembl

GeneID

KEGG

UCSC

ADPSP Organism specific

CTD

MGI

ADPSP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ADPSP Gene expression

Bgee

ArrayExpress

Genevestigator

ADPSP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY