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Human Kelch-like protein 20 (aa 1-609 )

KLEIP Swiss Prot#

Q9Y2M5

KLEIP Protein names

Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X)

KLEIP Gene names

KLHL20 KLEIP

Organism

Homo sapiens (Human)

KLEIP Entry name

KLH20_HUMAN

KLEIP Codon optimized cDNA(gene) Clone

KLEIP Cat #

RPY1513

Tag

KLEIP contains A 6x histidine tag

KLEIP Formulation

Liquid

KLEIP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

KLEIP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant KLEIP Protein

KLEIP Cat #

PY1513

KLEIP Source

recombinant

KLEIP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

KLEIP Purity

>90%, as determined by SDS-PAGE under reducing conditions

KLEIP Activity

N/A

Tag

KLEIP Contains A 6x histidine tag

KLEIP Formulation

Liquid

KLEIP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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KLEIP family

-

KLEIP Subcellular locations

Cytoplasm > perinuclear region. Nucleus.

KLEIP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.

KLEIP Sequence

DDBJ

EMBL

GenBank

KLEIP 3D structure

ModBase

KLEIP interaction

STRING

KLEIP Proteomic

PRIDE

KLEIP Genome annotation

Ensembl

GeneID

KEGG

UCSC

KLEIP Organism specific

CTD

MGI

KLEIP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

KLEIP Gene expression

Bgee

ArrayExpress

Genevestigator

KLEIP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY