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Rat Formin-binding protein 1-like (aa 1-605 )

Toca1 Swiss Prot#

Q2HWF0

Toca1 Protein names

Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)

Toca1 Gene names

Fnbp1l Toca1

Organism

Rattus norvegicus (Rat)

Toca1 Entry name

FBP1L_RAT

Toca1 Codon optimized cDNA(gene) Clone

Toca1 Cat #

RPY1504

Tag

Toca1 contains A 6x histidine tag

Toca1 Formulation

Liquid

Toca1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Toca1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Toca1 Protein

Toca1 Cat #

PY1504

Toca1 Source

recombinant

Toca1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Toca1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Toca1 Activity

N/A

Tag

Toca1 Contains A 6x histidine tag

Toca1 Formulation

Liquid

Toca1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Toca1 family

FNBP1 family

Toca1 Subcellular locations

Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Toca1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.

Toca1 Sequence

DDBJ

EMBL

GenBank

Toca1 3D structure

ModBase

Toca1 interaction

STRING

Toca1 Proteomic

PRIDE

Toca1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Toca1 Organism specific

CTD

MGI

Toca1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Toca1 Gene expression

Bgee

ArrayExpress

Genevestigator

Toca1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY