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Human Cdc42-interacting protein 4 (aa 1-601 )

CIP4 Swiss Prot#

Q15642

CIP4 Protein names

Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)

CIP4 Gene names

TRIP10 CIP4 STOT STP

Organism

Homo sapiens (Human)

CIP4 Entry name

CIP4_HUMAN

CIP4 Codon optimized cDNA(gene) Clone

CIP4 Cat #

RPY1491

Tag

CIP4 contains A 6x histidine tag

CIP4 Formulation

Liquid

CIP4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CIP4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CIP4 Protein

CIP4 Cat #

PY1491

CIP4 Source

recombinant

CIP4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CIP4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CIP4 Activity

N/A

Tag

CIP4 Contains A 6x histidine tag

CIP4 Formulation

Liquid

CIP4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CIP4 family

FNBP1 family

CIP4 Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Cytoplasm > perinuclear region.

CIP4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

CIP4 Sequence

DDBJ

EMBL

GenBank

CIP4 3D structure

ModBase

CIP4 interaction

STRING

CIP4 Proteomic

PRIDE

CIP4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CIP4 Organism specific

CTD

MGI

CIP4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CIP4 Gene expression

Bgee

ArrayExpress

Genevestigator

CIP4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY