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Mouse Merlin (aa 1-596 )

Nf-2 Swiss Prot#

P46662

Nf-2 Protein names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin)

Nf-2 Gene names

Nf2 Nf-2

Organism

Mus musculus (Mouse)

Nf-2 Entry name

MERL_MOUSE

Nf-2 Codon optimized cDNA(gene) Clone

Nf-2 Cat #

RPY1478

Tag

Nf-2 contains A 6x histidine tag

Nf-2 Formulation

Liquid

Nf-2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nf-2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nf-2 Protein

Nf-2 Cat #

PY1478

Nf-2 Source

recombinant

Nf-2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nf-2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nf-2 Activity

N/A

Tag

Nf-2 Contains A 6x histidine tag

Nf-2 Formulation

Liquid

Nf-2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Nf-2 family

-

Nf-2 Subcellular locations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm > cytoskeleton. Nucleus.

Nf-2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.

Nf-2 Sequence

DDBJ

EMBL

GenBank

Nf-2 3D structure

ModBase

Nf-2 interaction

STRING

Nf-2 Proteomic

PRIDE

Nf-2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nf-2 Organism specific

CTD

MGI

Nf-2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nf-2 Gene expression

Bgee

ArrayExpress

Genevestigator

Nf-2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY