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Human Merlin (aa 1-595 )

SCH Swiss Prot#

P35240

SCH Protein names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

SCH Gene names

NF2 SCH

Organism

Homo sapiens (Human)

SCH Entry name

MERL_HUMAN

SCH Codon optimized cDNA(gene) Clone

SCH Cat #

RPY1470

Tag

SCH contains A 6x histidine tag

SCH Formulation

Liquid

SCH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SCH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SCH Protein

SCH Cat #

PY1470

SCH Source

recombinant

SCH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SCH Purity

>90%, as determined by SDS-PAGE under reducing conditions

SCH Activity

N/A

Tag

SCH Contains A 6x histidine tag

SCH Formulation

Liquid

SCH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Place Order for Recombinant SCH Products

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SCH family

-

SCH Subcellular locations

Cell projection > filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection > ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm > perinuclear region. Cytoplasmic granule. Nucleus. Cell projection > filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection > ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm > perinuclear region. Cytoplasmic granule. Cytoplasm > cytoskeleton.

SCH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

SCH Sequence

DDBJ

EMBL

GenBank

SCH 3D structure

ModBase

SCH interaction

STRING

SCH Proteomic

PRIDE

SCH Genome annotation

Ensembl

GeneID

KEGG

UCSC

SCH Organism specific

CTD

MGI

SCH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SCH Gene expression

Bgee

ArrayExpress

Genevestigator

SCH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY