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Rat Merlin (aa 1-586 )

Nf2 Swiss Prot#

Q63648

Nf2 Protein names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Fragment)

Nf2 Gene names

Nf2

Organism

Rattus norvegicus (Rat)

Nf2 Entry name

MERL_RAT

Nf2 Codon optimized cDNA(gene) Clone

Nf2 Cat #

RPY1444

Tag

Nf2 contains A 6x histidine tag

Nf2 Formulation

Liquid

Nf2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nf2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nf2 Protein

Nf2 Cat #

PY1444

Nf2 Source

recombinant

Nf2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nf2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nf2 Activity

N/A

Tag

Nf2 Contains A 6x histidine tag

Nf2 Formulation

Liquid

Nf2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Nf2 family

-

Nf2 Subcellular locations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm > cytoskeleton. Nucleus.

Nf2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium (By similarity).

Nf2 Sequence

DDBJ

EMBL

GenBank

Nf2 3D structure

ModBase

Nf2 interaction

STRING

Nf2 Proteomic

PRIDE

Nf2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nf2 Organism specific

CTD

MGI

Nf2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nf2 Gene expression

Bgee

ArrayExpress

Genevestigator

Nf2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY